Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent
Organic & Biomolecular Chemistry(2019)
摘要
A practical approach to the direct alpha-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.
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关键词
dmso,metal-free
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