Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.

Denis A Babkov, Olga N Zhukowskaya,Alexander V Borisov, Valentina A Babkova,Elena V Sokolova,Anastasia A Brigadirova,Roman A Litvinov,Alexandra A Kolodina,Anatolii S Morkovnik,Vadim S Sochnev,Gennady S Borodkin,Alexander A Spasov

Bioorganic & Medicinal Chemistry Letters（2019）

Cited 32|Views7

No score

Abstract

•New biphenyl derivatives of tricyclic benzimidazoles were synthesized.•2′-Cyanobiphenyl was identified as novel pharmacophore of AMPK-activating activity.•Lead compounds demonstrate submicromolar potency towards AMPK.•One of lead compounds target AMPK and AT1 receptor simultaneously.•One of derivatives is a potent inhibitor of advanced protein glycation end-products.

Translated text

Key words

Fused benzimidazoles,Biphenyl,Antidiabetic activity,AMP-activated protein kinase

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined