Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi

Ana Cláudia Alvarenga Carneiro, G.P. Costa,Cyntia Silva Ferreira,Isalira Peroba Rezende Ramos,Mariáurea Matias Sarandy,Ana Luísa Junqueira Leite,A.P.J. Menezes,B.M. Silva,K.O.P.C. Nogueira, A.C.C. Carvalho,Reggiani Vilela Gonçalves,André Talvani

International Journal of Cardiology（2020）

Cited 5|Views13

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Abstract

•Dox was unable to improve ejection fraction in T. cruzi (VL-10 strain)-infected mice.•Dox did not ameliorate immune-parasitological parameters in T. cruzi-infected mice.•Benznidazole ameliorated ejection fraction in T. cruzi (VL-10 strain)-infected mice.•Benznidazole reduced parasitemia, CCL2/CCL5 plasma levels and cardiac infiltration.•Combination therapy with Dox does not potentiate the effects of benznidazole.

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Key words

Trypanosoma cruzi,VL-10 strain,Inflammation,Benznidazole,Doxycycline,Echocardiography

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