Synthesis of New Steroidal Quinolines with Antitumor Properties.

•New steroidal quinolines were synthesized via the Al2O3/KF-promoted pfitzinger reactions.•These new steroidal quinolines showed moderate to good antiproliferative activity against human lung cancer cells.•Compound 2f exhibited the best potency toward the tested three lung cancer cells with IC50 values <10 μM.•Compound 2f could be used as a hit compound for developing steroid-based anti-lung cancer agents.