A high-throughput LC-MS/MS method for the quantification of four immunosu- ppressants drugs in whole blood.

Zi-Shan Gong, Zhong-Hao Wu,Shu-Xin Xu,Wen-Nian Han,Xiao-Mei Jiang,Hai-Pei Liu, Yan-Li, Wei-Hu,Yan-Wang

Clinica Chimica Acta（2019）

引用 22|浏览7

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摘要

•A straightforward LC-MS/MS method was developed for determination of four immunosuppressant drugs.•One-step protein precipitation was used to deal with the blood samples, which was easy and high throughput.•Systematic evaluation were validated to access the method strictly according to the guidelines

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关键词

LC-MS/MS,Immunosuppressant drugs,Protein precipitation,Whole blood,Method verification

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