Detection of residual HCV-RNA in patients who have achieved sustained virological response is associated with persistent histological abnormality.
EBioMedicine(2019)
Abstract
HCV-RNA can persist in hepatocytes and/or PBMC in a certain of patients who achieved spontaneous or treatment-induced HCV RNA clearance from serum and associated with persistent histological abnormality. Our findings provide new insights into cure of HCV and could influence the following-up scenario after SVR.
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Key words
Occult hepatitis C,Direct-acting antiviral agents,RNAscope assay,Liver fibrosis,Hepatic pathology
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