Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements.

Meng Yang,Yu Seby Chen,Muneyoshi Ichikawa,Daniel Calles-Garcia,Kaustuv Basu,Rayan Fakih,Khanh Huy Bui,Kalle Gehring

Journal of Structural Biology（2019）

引用 4|浏览16

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摘要

•Cryo-EM structures of ArnA, an essential enzyme for polymyxin resistance.•ArnA exists as both hexamer and tetramer.•The results light on ArnA oligomer assembly process and its catalysis mode.

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关键词

Polymyxin,Cryo-EM,ArnA

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