A comparison study on efficacy, insulin sensitivity and safety of Glimepiride/Metformin fixed dose combination versus Glimepiride single therapy on type 2 diabetes mellitus patients with basal insulin therapy.

•Combination of oral hypoglycemic agents and insulin has the synergistic effect.•Glimepiride/metformin/insulin was more effective than high dose glimepiride/insulin.•Glimepiride/metformin/insulin and high dose glimepiride/insulin are relatively safe.