DNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds in embryo-fetal chicken livers.

Tetyana Kobets,Jian-Dong Duan,Klaus D Brunnemann,Esther Vock,Ulrich Deschl,Gary M Williams

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

引用 6|浏览15

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摘要

•24 cyclic compounds were assessed for DNA reactivity in embryo-fetal chicken livers.•Unsubstituted compounds yielded negative results.•Most compounds with various substitutions produced DNA damage.•Substituted polycyclic compounds were more potent compared to monocyclic chemicals.•These finding support use of chicken egg model for structure-activity assessment.

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关键词

Structure-activity relationship,DNA reactivity,Mono- and polycyclic compounds,Unsubstituted and substituted chemicals,Embryo-Fetal chicken livers

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