A single-step isolation by centrifugal partition chromatography of the potential anti-inflammatory glaucolide B from Lepidaploa chamissonis.

Layzon Antonio Lemos Da Silva,Louis P Sandjo,Eduarda Fratoni,Yeo Jim Kinoshita Moon,Eduardo Monguilhott Dalmarco,Maique Weber Biavatti

Journal of Chromatography A（2019）

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摘要

•Optimized leaves washing extraction was used to obtain a selective SL extract.•A single-step CPC purification afforded glaucolide B (yield, 25%) with 97% purity.•Glaucolide B was isolated for the first time from L. chamissonis leaves.•Glaucolide B inhibited the NO and IL-6 secretion on LPS-stimulated RAW 264.7 cells.

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关键词

Centrifugal partition chromatography (CPC),Glaucolide B,Sesquiterpene lactone,Lepidaploa chamissonis,Anti-inflammatory activity

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