Survival analysis of breast cancer patients with different treatments: a multicentric clinicopathological study.

Objective: To explore and better understand clinicopathological details of breast cancer patients and analyse their survival rate among different treatment groups. Methods:The prospective cohort, multi-centric study was conducted from September, 2014, to February, 2018, at five hospitals in Rawalpindi and Islamabad, Pakistan, and comprised histo-pathologically confirmed breast cancer cases. Patient characteristics and medical history were collected using a detailed questionnaire. All the subjects were followed up, and information regarding their current health and treatment status was collected. Data was analysed using SPSS 24. Results: There were 347 subjects with a mean age of 44.3 +/- 12.2 years and body mass index of 27.9 +/- 4.0 kg/m(2).Younger age, increased body mass index, consanguinity and family history were major contributing factors in breast cancer development (p<0.05). Overall, 267(77%) had invasive ductal carcinoma and Grade II tumour 234(67%) was more frequent. A total of 221(64%) cases had positive lymph nodes and 97(28%) had metastasis to different body organs. Overall survival analysis showed statistically significant role (p<0.0001) of all treatment options. Conclusion: Combination of different treatments can provide more promising health outcomes in breast cancer cases.