TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice.
Metabolism(2019)
摘要
•MN6 potently activated TGR5 and stimulated GLP-1 secretion.•MN6 improved glucose homeostasis in ob/ob and DIO mice.•MN6 enhanced insulin-stimulated glucose uptake in skeletal muscles of DIO mice.•MN6 prevented palmitate-induced insulin resistance in C2C12 myotubes.•MN6 ameliorated palmitate-induced insulin resistance by TGR5/cAMP/PKA pathway.
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关键词
AC,cAMP,DIO,DPP-4,EDL,FXR,GLP-1,HFD,ITT,LCA,OGTT,PKA,TGR5,UCP1
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