Inferring structure and parameters of dynamic systems using particle swarm optimization.

Inferring models of dynamic systems from their time series data is a challenging task for optimization algorithms due to its potentially expensive computational cost and underlying large search space. In this study we aim to infer both the structure and parameters of a dynamic system model simultaneously by Particle Swarm Optimization (PSO), enhanced by effective stratified sampling strategies. More specifically we apply Latin Hyper Cube Sampling (LHS) with PSO. This leads to two novel swarm-inspired algorithms, LHS-PSO which can be used efficiently to learn the structure and parameters of simple and complex dynamic system models. We used a complex biological cancer model called Kinetochores, for assessing the performance of PSO and LHS-PSO. The experimental results demonstrate that LHS-PSO can find promising solutions with corresponding structure and parameters, and it outperforms PSO during our experiments.