Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms.

Journal of Pharmaceutical and Biomedical Analysis(2019)

Cited 20|Views32
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Abstract
•UHPLC-MS/MS method developed for comparative pharmacokinetics of nine active components of Semen Cassiae in rats.•Method development and validation following the latest implemented FDA guideline.•Dosage conversion between ultrafine granular powder and traditional pieces of Semen Cassiae.
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Key words
Semen Cassiae,Ultrafine granular powder,UHPLC-MS/MS,Pharmacokinetics,Dosage
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