Adenovirus-vectored African Swine Fever Virus antigen cocktails are immunogenic but not protective against intranasal challenge with Georgia 2007/1 isolate.

Shehnaz Lokhandwala,Vlad Petrovan,Luca Popescu,Neha Sangewar,Catherine Elijah,Ana Stoian,Matthew Olcha, Lindsey Ennen,Jocelyn Bray,Richard P Bishop,Suryakant D Waghela,Maureen Sheahan,Raymond R R Rowland,Waithaka Mwangi

Veterinary Microbiology（2019）

Cited 43|Views21

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Abstract

•Adeno-vectored ASFV antigen cocktail in ZTS-01 adjuvant conferred 56% (5/9) survival.•Survivors were healthy and non-viremic at termination.•Two out of five cognate controls were alive at study termination, but one pig was moribund.•Adeno-vectored ASFV antigen cocktail in BioMize adjuvant conferred 20% (2/10) survival, but one pig was moribund.•Two out of five cognate controls were alive at study termination, but one pig was moribund.

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Key words

Swine,African Swine Fever Virus,Adenovirus,Prototype subunit vaccine,Efficacy

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