mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.

Nuria Martinez,Catherine Y Cheng,Natkunam Ketheesan, Aidan Cullen,Yuefeng Tang,Josephine Lum,Kim West,Michael Poidinger,David A Guertin,Amit Singhal,Hardy Kornfeld

EBioMedicine（2019）

引用 18|浏览89

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摘要

Our study reveals a systemic response to aerosol M. tuberculosis infection that regulates adipose tissue lipid homeostasis through mTORC2/Akt signaling in adipocytes. Adipose tissue inflammation in TB is not simply a passive infiltration with leukocytes but requires the mechanistic participation of adipocyte signals.

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关键词

Tuberculosis,Adipose tissue,Inflammation,mTORC2,Akt,Insulin resistance

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