Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis

•Meropenem pharmacokinetics/pharmacodynamics in paediatric patients with bacterial meningitis.•Study of 154 paediatric patients, including 109 patients with bacterial meningitis.•Analysis based on T>MIC using meropenem concentration in cerebrospinal fluid (CSF).•Thirty-six patients with satisfactory clinical cure showed at least 75.3%T>MIC(CSF).•Meropenem 40 mg/kg q8h is necessary for paediatric patients with bacterial meningitis.