Increased intracellular Cl− concentration mediates Trichomonas vaginalis-induced inflammation in the human vaginal epithelium

Jian-Bang Xu,Yi-Lin Zhang,Jiehong Huang,Shen-Jiao Lu,Qing Sun,Peng-Xiao Chen,Ping Jiang,Zhuo-Er Qiu,Fu-Neng Jiang,Yun-Xin Zhu,De-Hua Lai,Wei-De Zhong,Zhao-Rong Lun,Wen-Liang Zhou

International Journal for Parasitology（2019）

引用 8|浏览20

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摘要

•Trichomonas vaginalis triggered inflammation and an increase in [Cl−]i in the vaginal epithelium.•Cysteine proteases were implicated in T. vaginalis-elicited down-regulation of CFTR.•There was increased [Cl−]i mediated vaginal epithelial inflammation via SGK1 activation.•Up-regulation of phosphodiesterase 4 degraded cAMP and promoted disequilibrium in [Cl−]i.

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关键词

Trichomonas vaginalis,Vaginal inflammation,Cysteine proteases,CFTR,SGK1,PDE4

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