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Indoleamine-2,3-dioxygenase-1 expression predicts poorer survival and up-regulates ZEB2 expression in human early stage bladder cancer.

Yuh-Shyan Tsai,Yeong-Chin Jou,Hsin-Tzu Tsai,Ian-Seng Cheong,Tzong-Shin Tzai

Urologic Oncology: Seminars and Original Investigations（2019）

Cited 12|Views10
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Abstract
•There was a higher frequency of IDO1 expression in human urothelial carcinoma.•The urine tryptophan metabolite levels are increased in urothelial cancer patients.•IDO1 expression is an independent worse prognostic factor in bladder cancer patients.•IDO1 can upregulate ZEB2 expression through miR-200c signaling.
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Key words
Bladder neoplasm,Indoleamine-2,3-dioxygenase-1,Epithelial-mesenchymal transition,Prognosis
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