Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit-related receptors on antigen-presenting cells and induces T H 2/T H 17 polarization through dectin-2.

Yunsheng Liang,Bihui Yu,Junchen Chen,Haijin Wu,Yingping Xu,Bin Yang,Qianjin Lu

Journal of Allergy and Clinical Immunology（2019）

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摘要

TSLP mediated upregulation of FcRγ-related receptors on APCs through activation of pSTAT5, which recruited TET2 to induce FCER1G demethylation. TSLP-induced allergic T2/T17 polarization likely depends on dectin-2-mediated allergen sensitization and upregulation of T2/T17-related cytokines.

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关键词

Atopic dermatitis,thymic stromal lymphopoietin,signal transducer and activator of transcription 5,ten-eleven translocation protein 2,DNA demethylation,FcRγ-related receptors,dectin-2,allergen uptake,IL-33,IL-25,TH2/TH17 polarization

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