The Effect Of Nonpharmacologic Therapy On Global Cognitive Functions In Patients With Alzheimer'S Disease: An Updated Meta-Analysis Of Randomized Controlled Trials
INTERNATIONAL JOURNAL OF NEUROSCIENCE(2020)
摘要
Background: The effectiveness of non-pharmacologic therapy (NPT) in treating the global cognition dysfunction associated with Alzheimer's disease (AD) has not been clearly demonstrated. Therefore, we performed a meta-analysis to address this issue. Methods: The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE and other databases were searched, and outcomes measured by the Mini-Mental State Examination (MMSE) or the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) were analysed. Results: Seven types of NPT were included, 25 randomized controlled trials (RCTs) were selected and 3238 participants were included in the meta-analysis. There were significant differences between the NPT and control groups in the MMSE and ADAS-cog scores. Conclusions: Although more extensive trials need to be performed, NPT has been observed to be beneficial in AD patients.
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关键词
Nonpharmacologic therapy, global cognition functions, Alzheimer's disease, systematic review, meta-analysis
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