A Selective Inhibitor of Ubiquitin-Specific Protease 4 Suppresses Colorectal Cancer Progression by Regulating β-Catenin Signaling.

Hoa Hong Nguyen,Truc Kim,Thanh Nguyen,Myong-Joon Hahn,Sun-Il Yun,Kyeong Kyu Kim

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

The current results suggest that NR could be developed as an anticancer drug targeting USP4, and they support the possibility of developing specific DUB inhibitors as therapeutic agents.

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关键词

Beta-catenin,Colorectal Cancer,Deubiquitinating Enzyme,Noncompetitive Inhibitor,USP4

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