Reply to Furlan et al.: The role of SIRT1 in cell autonomous clock function.

As the mathematical model developed by Woller et al. (1) also considers the role of SIRT1 in circadian clock, we regret not citing this work. However, we feel the inferences drawn in Furlan et al.’s (2) letter conflate 2 distinct studies with disparate purposes and methods. In Foteinou et al. (3), we address the role of SIRT1 in cell-autonomous clock function. We undertook this experimentation and modeling to resolve the conflicting reports by Asher et al. (4) and Nakahata et al. (5), elucidating … [↵][1]5To whom correspondence may be addressed. Email: frank_doyle{at}seas.harvard.edu. [1]: #xref-corresp-1-1