Curcumin attenuates insulin resistance and hepatic lipid accumulation in a rat model of intrauterine growth restriction through insulin signaling pathway and SREBPs.

The objective of the present study was to investigate the effect of curcumin on insulin resistance (IR) and hepatic lipid accumulation in intra-uterine growth restriction (IUGR). Rats with a normal birth weight (NBW) or IUGR were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NBW-C and IUGR-C groups) from 6 to 12 weeks. Rats in the IUGR group showed higher levels of glucose and homeostasis model assessment for insulin resistance index (HOMA-IR) (P < 0 center dot 05) than in the NBW group. The livers of IUGR rats exhibited higher (P < 0 center dot 05) concentration of TAG and lower (P < 0 center dot 05) activities of lipolysis enzymes compared with the normal rats. In response to dietary curcumin supplementation, concentrations of serum insulin, glucose and HOMA-IR, pyruvate, TAG, total cholesterol and NEFA in the liver were decreased (P < 0 center dot 05). The concentrations of glycogen and activities of lipolysis enzymes in the liver were increased (P < 0 center dot 05) in the IUGR-C group compared with the IUGR group. These results were associated with lower (P < 0 center dot 05) phosphorylated insulin receptor substrate 1, protein kinase B or Akt, glycogen synthase kinase 3 beta and expressions of sterol regulatory element binding protein 1 and fatty acid synthase (FASN); decreased expressions for Cd36, sterol regulatory element binding protein 1c (Srebf1) and Fasn; increased (P < 0 center dot 05) expression of PPAR alpha; and expressions for Ppara and hormone-sensitive lipase in the liver of IUGR-C rats than the IUGR rats. Maternal malnutrition caused IR and lipid accumulation in the liver. Curcumin supplementation prevented IR by regulating insulin signalling pathways and attenuated hepatic lipid accumulation.