Autoantibody-positivity in lean type II diabetes patients was associated with elevated Th17-like CD4 + CXCR5 + T cell responses.

Yiran Wang, Wenwen Li,Jingjing Zhou,Renhui Wan,Wei Hao,Ye Gao,Yifei He,Rong Chen,Xiao Zhai,Qijin Wang

Molecular Immunology（2019）

引用 4|浏览6

暂无评分

摘要

•We investigated the follicular helper T (Tfh) cells in lean T2D patients.•The composition of Tfh subsets in lean T2D patients was altered.•Tfh cells in T2D patients were enriched with CCR6+ and IL-17+ Th17-like subsets.•Th17-like Tfh frequency was associated with the presence of autoantibodies.•CCR6+ Tfh cells were more effective at promoting antibody secretion.

查看译文

关键词

CXCR5+CD4+ T cell,Normal body-mass index,Th17,Type II diabetes

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要