MicroRNA-181d associated with the methylation status of the MGMT gene in Glioblastoma multiforme cancer stem cells submitted to treatments with ionizing radiation and temozolomide.

Fermino Sanches Lizarte Neto,Andressa Romualdo Rodrigues,Felipe Amstalden Trevisan,Mucio Luiz de Assis Cirino,Caio César Marconato Simões Matias,Gabriela Pereira-da-Silva,Fernanda Maris Peria,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti

Brain Research（2019）

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摘要

•Ionizing radiation and temozolomide reduced the viability of CSCs from GBM patients.•Ionizing radiation and temozolomide were able to modify expression MGMT gene of GCSCs.•miR-181d interferes in the CSCs response submitted to standard treatment from GBM.

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关键词

Glioblastoma,MGMT,microRNA,Temozolomide,Ionizing radiation

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