A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

JOURNAL OF CELL BIOLOGY（2019）

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摘要

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

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