Genetic susceptibility to nicotine and/or alcohol addiction: a systematic review

Recent studies have confirmed the wide consumption of tobacco and alcohol in our society and the strong addiction generated by these substances, which is responsible for high public health expenditure. Understanding the biological mechanisms of nicotine and/or alcohol dependence should have huge public health repercussions in the future. The aim of this review was to analyze the main human genes and polymorphisms related to nicotine and/or alcohol addiction, to help understand the biological mechanisms involved and which may be useful for developing new treatments in the future.