Modeling Mania At The Cellular Level

In vitro models of disease are essential to preclinical and translational attempts at understanding human diseases. Within psychiatric research, there is an increased ability to examine living neuronal cells directly in the form of induced pluripotent stem cell (iPSC) lines or olfactory neuroepithelial cell progenitor (ONP) lines. However, to be able to examine these cells directly, one needs to be able to model, at the cellular level, complex conditions that have behavioral, not just physiological, manifestations.