50. New Roles for Peripheral Dopamine D2-Like Receptors in Antipsychotic Drug-Induced Metabolic Dysfunction

Antipsychotic drugs (APDs) are some of the most widely used medications today. However, APDs also share prominent metabolic side effects, including weight gain, insulin resistance, and increased diabetes risk. The unifying property of all APDs is their blockade of dopamine D2-like receptors including D2 (D2R) and D3 receptors (D3R), suggesting the receptors' roles in metabolic disturbances. Besides brain expression, D2R and D3R are expressed in insulin-secreting pancreatic beta cells. Thus, we investigated D2R/D3R-mediated effects on glucose-stimulated insulin secretion (GSIS) and APD action directly in mouse pancreatic islets and INS-1E cells, a well-established rodent beta cell-derived cell line.