Cover Feature: Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides (Asian J. Org. Chem. 5/2019)

Asian Journal of Organic Chemistry(2019)

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摘要
C−F bonds are usually inert and stable, but when using certain catalysts, the C−F bond can be easily transformed into a C−O bond, despite the bond-dissociation energy barrier. In fact, fluorine is a much better communicator than other halogens such as chlorine, when assisted by silicon and an organic base. More information can be found in the Communication by Norio Shibata et al. on page 641 in Issue 5, 2019 (DOI: 10.1002/ajoc.201900157). Graphic credit: Mami Shibata, a painter of Japanese art; the title of her work is “Koeno no Katachi” (Communications).
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catalytic desymmetrization,epoxides
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