Celecoxib Augmentation Of Escitalopram In Treatment-Resistant Bipolar Depression And The Effects On Quinolinic Acid In The Kynurenine Pathway
BIOLOGICAL PSYCHIATRY(2019)
Abstract
•Patients receiving escitalopram+celecoxib showed improved response and a higher remission rate.•Patients had significantly lower Quinolinic Acid levels at baseline compared to healthy controls.•Quinolinic Acid values did not change significantly over time, but a downtrend was noted throughout the treatment.•Responders had marginally lower Quinolinic Acid values than non-responders.•Prior exposure to a variety of psychoactive drugs may explain the negative findings.
MoreTranslated text
Key words
Celecoxib, Escitalopram, Kynurenine Pathway, Quinolinic Acid, Picolinic Acid, Bipolar Disorder, Neuroinflammation
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined