Impaired Fear Extinction In Omega-3 Fatty Acid Deficient Rats Is Attenuated By Chronic Amphetamine Treatment
BIOLOGICAL PSYCHIATRY（2019）
Abstract
Mood disorders are associated altered prefrontal cortex (PFC) and amygdala (AMY) structural and functional connectivity, and deficits in the omega-3 fatty acid docosahexaenoic acid (DHA). Reciprocal connections between the rat PFC and basolateral AMY mediate conditioned fear acquisition and extinction, and this circuit undergoes robust synaptic pruning during adolescence. DHA promotes synaptogenesis and synaptic pruning, and chronic amphetamine (AMPH) treatment induces synaptic reorganization in the rat PFC. The present study investigated whether developmental deficits in brain DHA accrual and/or chronic AMPH exposure impact fear conditioning in young adulthood.
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Key words
Amphetamine, N-3 Fatty Acids, Fear Conditioning, Developing Brain
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