New players in the gene regulatory network controlling late B cell differentiation

•Multiple intrinsic and extrinsic inputs control B cell terminal differentiation.•Differentiation is associated with loss of CpG methylation at promoters/enhancers.•Ezh2 functions a several points to coordinate the B cell to plasma cell transition.•B cell terminal differentiation is associated with changes in genome architecture.•The B1 cell subset utilizes distinct regulatory factors.