Functional Connectivity Of The Locus Coeruleus Identifies Individuals At Familial Risk For Alzheimer'S Disease

Ines Del Cerro,Mirta F. Villarreal,Carolina Abulafia,Barbara Duarte-Abritta,Stella M. Sanchez,Marina N. Castro,Hernan Bocaccio,Isidro Ferrer,Jose M. Menchon,Gustavo Sevlever,Carles Soriano-Mas,Salvador M. Guinjoan

Biological Psychiatry（2019）

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摘要

Prevention and early treatment strategies for Alzheimer's Disease (AD) are hampered by the lack of risk biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neuroprotective role in LC projecting areas. We assessed functional connectivity (FC) of the brainstem in asymptomatic individuals at familial risk for AD hypothesizing that FC of the LC will be decreased in relation to not-at-risk individuals.

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关键词

Alzheimer's Disease, Locus Coeruleus, Resting State Functional Connectivity MRI (fcMRI), Early Risk Detection, Biomarkers

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