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Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

Eva Drazanova,Lucie Kratka,Nadezda Vaskovicova,Radim Skoupy,Katerina Horska,Zuzana Babinska,Hana Kotolova,Lucie Vrlikova,Marcela Buchtova,Zenon Starcuk,Jana Ruda-Kucerova

Pharmacological Reports（2019）

Cited 6|Views24
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Abstract
•Olanzapine decreased cortical perfusion after acute and chronic olanzapine exposure.•Chronic olanzapine decreased cortical volume.•Suppression of blood perfusion may contribute to later structural impairment.
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Key words
Arterial spin labelling,Cortex,Leptin,Olanzapine,Sprague-Dawley rats
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