400A – Effect of Initiating Aspirin on Cancer Events in the Healthy Elderly: Primary Results from the Aspree Randomized Controlled Trial

Helminth naïveHelminth exposed p value MLN MLN % CD4+ YFP+ cells 8.9 ± 1.3 % 4.5 ± 0.3 % < 0.05 % CD4+ YFP+ cells 3.3 ± 1.4 % 0.8 ± 0.2 % < 0.05 expressing IFNγ % CD4+ YFP+ cells 3.1 ± 1.6 % 8.8 ± 1.5 % < 0.05 expressing IL10 %CD4+ YFP+ cells 3.6 ± 0.5 % 8.1 ± 1.7 % < 0.05 expressing Foxp3 % proliferation on co-culture with 19.4 ± 3.2 % 7.7 ± 2.1 < 0.05 YFP+ cells from % suppression of in 29.0 ± 4.2 % 66.7 ± 3.3 % < 0.01 vitro proliferation * T cell transfer colitis score** with co-3.6 ± 0.5 0.5 ± 0.2 < 0.05 administered YFP + from Results are mean + SE from at least three separate experiments.*compared to mitogenstimulated spleen cells without any co-cultured YFP+ cells, ** 0-4 histology score; 0 = normal, 4 = consistent ulceration, transmural inflammation, and mucus depletion