Identification and characterization of ‘readers’ for novel histone modifications

•Crosslinking and screening strategies facilitate the discovery of histone readers.•Epigenome editing tools enable the incorporation of histone modifications in cells.•ZZ domain and Agenet domain are new readers recognizing histone H3un/K4ac and H3K9me2.•Serotonylation and benzoylation are new modifications regulating gene expression.