Sa1945 – Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review of Randomized-Controlled Trials

with no prior CPAP treatment.The prevalence of functional GI disorders (diagnosed by Rome III criteria) and each GI symptom were compared between patients with adequate CPAP usage and with no prior CPAP usage.Results: Baseline characteristics except for age were similar between the 2 groups (Table 1).Most patients had severe OSA with similar baseline apnea-hypopnea index (AHI) (adequate CPAP vs. no prior CPAP: 46±24 vs. 52±21, p=0.27).Patients with adequate CPAP use (CPAP usage 259±16 minutes/day and 90±13% used days) had normalized AHI after treatment (2.96±3.2).The prevalence of abdominal pain was significantly lower in patients receiving adequate CPAP treatment compared to patients with no prior treatment (22.2% vs. 5.6%, p=0.03).In addition, the prevalence of reflux symptoms (heartburn/regurgitation) and diagnosis of irritable bowel syndrome (IBS) were significantly lower in adequate treatment group compared to no prior CPAP treatment group (25% vs. 44.4%,p = 0.05 and 2.8% vs. 17.7%, p= 0.03); respectively.Prevalences of abdominal discomfort, constipation symptoms (hard stool, incomplete evacuation, strain, sense of blockage, and need for digital maneuver), morning urge and postprandial urge frequency, stool frequency, and overall GI symptoms were not significantly different between groups (p>0.05)(Table2).Prevalence of bloating, a potential adverse effect of CPAP treatment, and proton-pump inhibitors usage, which can affect the GI symptoms, were not significantly different between groups (30.2% vs. 36.1%,p=0.54 and 15.9% vs. 16.7%,p=0.92); respectively.Multivariate analysis showed that adequate CPAP usage was independently associated with lower prevalence of IBS after adjusted for age, gender and BMI with odds ratio=0.12,95%CI 0.02-0.98,p=0.049.Conclusions Although GI symptoms were prevalent in OSA patients, adequate CPAP treatment was associated with significant lower prevalence of IBS, typical reflux symptoms and abdominal pain.Further studies regarding the effects of CPAP on GI physiology are warranted.Table 1: Baseline characteristics comparing between OSA patients with adequate CPAP usage and no prior CPAP usage