G-CSF-mobilized blood and bone marrow grafts as the source of stem cells for HLA-identical sibling transplantation in patients with thalassemia major.

Qiaochuan Li,Jianming Luo,Zhongming Zhang,Lianjin Liu,Lin Luo,Gaohui Yang,Rongrong Liu,Lingling Shi, Rui Huang,Meiqing Wu,Yongrong Lai

Biology of Blood and Marrow Transplantation（2019）

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摘要

•Granulocyte colony-stimulating factor-mobilized blood and bone marrow graft transplantation proved to be an effective approach to treating thalassemia major.•Antithymocyte globulin- and fludarabine-containing myeloablative conditioning regimens were associated with low rates of graft-versus-host disease and graft rejection.•Close chimerism monitoring and early intervention effectively prevented graft rejection.

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关键词

Peripheral blood stem cell transplantation,Bone marrow transplantation,Thalassemia major,Sibling donor

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