A DNA vaccine expressing an optimized secreted FAPα induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer.
Vaccine（2019）
Abstract
•An optimized FAPα-targeted DNA vaccine was constructed.•DNA sequence homology between optimized FAPα and original FAPα was only 76%.•The vaccine induced more FAPα-specific CD8+ T cells.•Clearance of CAFs decreased the infiltration of MDSCs in tumor.•Mouse FAPα vaccine and human FAPα vaccine had similar anti-tumor effects.
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Key words
FAPα,Cancer-associated fibroblast,Tumour microenvironment,Myeloid-derived suppressor cell,DNA vaccine,Cancer immunotherapy
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