Efficiency of different fragment lengths of the ubiquitous chromatin opening element HNRPA2B1-CBX3 in driving human CD18 gene expression within self-inactivating lentiviral vectors for gene therapy applications.
Gene（2019）
Abstract
Patients with leukocyte adhesion deficiency type 1 (LAD1) suffer from life-threatening bacterial infections due to mutations in the common β2 integrin subunit (CD18/ITGB2 gene).
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Key words
LAD,CLAD,LV,SIN,EF1α,PGK,MSCV,ITGB,HNRP,CBX,UCOE,HEK,EBV,HSC,BES,BBS,MTA,RPMI,SCF,TPO,Flt3,FITC,7-AAD,MOI
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