Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives.

Background: In the recent past, we have synthesized and repotted different derivatives of oxadiazoles as potential alpha-glucosidase inhibitors, keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on the chemistry and bioactivity of new heterocyclic compounds. Methods: 1,3,4-Oxadiazole derivatives (1-14) have been synthesized and characterized by different spectroscopic techniques such as H-1,-C-1(3)-NMR and HREI-MS. Results: The synthetic derivatives were screened for alpha-glucosidase inhibitory potential. All compounds exhibited good inhibitory activity with IC50 values ranging between 0.80 +/- 0.1 to 45.1 +/- 1.7 mu M in comparison with the standard acarbose having IC50 value 38.45 + 0.80 mu M. Conclusion: Thirteen compounds 1-6 and 8-14 showed potential inhibitory activity as compared to the standard acarbose having IC50 value 38.45 1 0.80 mu M, however, only one compound 7 (IC50 = 45.1 +/- 1.7 mu M) was found to be less active. Compound 14 (IC50 - 0.80 +/- 0.1 mu M) showed promising inhibitory activity among all synthetic derivatives. Molecular docking studies were also conducted for the active compounds to understand the ligand-enzyme binding interactions.