A Systematic Review of the Relative Frequency and Risk Factors for Prolonged Opioid Prescription Following Surgery and Trauma Among Adults.
ANNALS OF SURGERY(2020)
摘要
Supplemental Digital Content is available in the text Objective: The aim of this study was to examine the relative frequency of and risk factors for prolonged opioid prescription (Rx_3-6: >= 1 opioid prescription of any length between 3 and 6 months postevent) and long-term opioid prescription (Rx_>6: >= 1 opioid prescription of any length >6 months postevent) after surgery/trauma. Summary Background Data: Eighty percent of patients undergoing surgery are prescribed opioids; for many this initial time-limited therapy continues for months after surgery. Methods: Included studies were published between January 1998 and April 2018, examined opioid use >= 3 months after surgery/trauma requiring hospitalization, and considered pre-event opioid prescription status. Empirical studies were identified via a systematic literature search. Two independent reviewers assessed studies for inclusion and conducted data extraction and quality appraisal. Results: Thirty-five of the 10,003 screened articles were included; most were retrospective studies of medicoadministrative databases; all studies were observational. The median relative frequency of Rx_3-6 and Rx_>6 was 4.1% and 2.6%, respectively, among patients with no/short-term opioid prescription pre-event and 50.9% and 58.5%, respectively, among patients with prolonged opioid prescription pre-event. Income levels, tobacco dependence, use of antidepressants, and pre-event opioid prescriptions are associated with increased risk of Rx_3-6/Rx_>6. The use of benzodiazepines (current use) or muscle relaxants and the presence of alcohol/drug dependence were found to be potential risk factors for Rx_3-6/Rx_>6 among patients with no/short-term opioid prescription pre-event. Conclusions: Identified risk factors for Rx_3-6/Rx_>6 were predominantly psychosocial factors. This points to the importance of assessing mental and social health before surgery and acutely during hospitalization to ensure safe and optimal recovery.
更多查看译文
关键词
frequency,long-term opioid prescription,opioids,postoperative,risk factors,surgery,systematic review,trauma
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要