Design of immunogens: The effect of bifunctional chelator on immunological response to chelated copper.
Journal of Pharmaceutical and Biomedical Analysis（2019）
Abstract
•ρ-SCN-Bn-NOTA was the optimal chelator for preparing copper immunoconjugate.•McAb named 4B7 specific to Cu2+-NOTA was screened by hybridoma.•The developed icELISA improved the performance of immunoassay for Cu2+.
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Key words
Copper ions,Bifunctional chelator,Immunogen,Monoclonal antibody,Immunological response
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