Antemortem histopathology and imaging findings in a case of Marchiafava-Bignami disease.

•Only available case report in the literature to describe antemortem histopathology changes of Marchiafava-Bignami disease.•Describes the history behind the disease’s name.•Gives insight into possible presentation scenarios.•Includes clinical, radiology and histopathology description of the disease.•Describes the available classifications for this disease.