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非编码RNA与肝衰竭关系的研究进展

Y Wang,L W Wang,Z J Gong

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology（2019）

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Abstract
肝衰竭是常见的危重疾病,临床上无良好的早期诊断指标和治疗方法.研究显示,以微小RNA (miRNA)和长链非编码RNA (lncRNA)为代表的非编码RNA (ncRNA)不仅可以作为肝衰竭的早期诊断指标,也在肝衰竭炎性反应、肝细胞死亡和肝细胞再生过程中发挥着重要的调控作用,同时ncRNA参与的表观遗传调控也参与肝衰竭的发生和发展.现就miRNA和lncRNA与肝衰竭的关系进行综述,以期为肝衰竭的诊断与治疗寻找新的作用靶点.
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Key words
Liver failure,lncRNA,miRNA
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