Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.

•BGN protein expression is a novel independent marker for adverse oncological outcome in bladder cancer.•The prognostic role of BGN was validated in the external TCGA cohort on mRNA level.•BGN correlates with key indicators for epithelial-mesenchymal transition (EMT).•Gene set enrichment analysis correlated BGN expression with EMT and bladder cancer gene signatures.•BGN expression correlates with the molecular basal subtype in BC.