Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells.

Bao-Ping Xie,Li-Ying Shi,Jin-Ping Li,Ying Zeng,Wei Liu,Si-Yuan Tang,Lu-Juan Jia, Jie Zhang,Guo-Xing Gan

Biomedicine & Pharmacotherapy（2019）

Cited 29|Views16

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Abstract

•Estrogen receptor is the target of oleanolic acid.•Oleanolic acid up-regulates miR-503 expression through ERα.•Oleanolic acid inhibits osteoclasts by up-regulating miR-503 expression.

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Key words

Cat-k,E2,ELISA,ER,ERE,Mmp-9,MPP,mRNAs,OA,Rank,Trap

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