TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis.
Biochemical and Biophysical Research Communications(2019)
摘要
TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway. Oxidative stress-induced neuronal apoptosis is the pathological basis of several neurological disorders, including epilepsy. To determine the potential anti-epileptic action TIGAR in a rodent kainic acid (KA)-induced seizure model.
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关键词
Epilepsy,TIGAR,Oxidative stress,Neuronal apoptosis
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